Cognistem Biosciences LLC, located in La Jolla CA, is developing induced pluripotent stem (iPS)-derived neuronal models to study the cellular and molecular phenotypes associated with Alzheimer’s disease. Patient-derived iPS cells are valuable tools for developing personalized diagnostics, therapeutic drugs and models of disease. We are engaged in modeling the different subtypes of Alzheimer’s disease in neurons and 3D cerebral organoids derived from patients’ own iPS cells in order to understand the onset and progression of Alzheimer’s disease in individual patients and to develop and test therapies.